Molecular docking analysis of selected bioactive components of Glycyrrhiza glabra against bronchial asthma

Bronchial asthma is a chronic inflammatory disease of the lung by combined action various cytokines. As result strong response increased infiltration cytokines result, damages respiratory epithelium, Hyperplasia trachealis muscle, and mucous production. Athimathura choornam promising drug used in all conditions. Objective: To explore efficacy Siddha formulation choornam, an anti asthmatic using computational molecular docking analysis. Method: Based on phytochemical study active principles present plant Athimathuram were retrieved. 3D structure targets retrieved from repository purified before initiation software. The potency was screened based binding ligands Asparagine, Liquiritin, Glabridin with mentioned. These results compared standard drugs such as Cetirizine, Salicylic acid, Diclofenac, Ibuprofen, Celecoxib. Results Conclusion: Liquiritin has 9 interactions (90%) similar to that 14 Citrazinehence , 5 (100%) salicylic acid hence it COX 1 inhibition ,Histamine blocking activity Prostaglandin Synthase activity. Asparagine 3 (60%) Celecoxib, 2 (50%) Diclofenac IL6